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Bovine Coagulation

Zymogens

Bovine Protein C

Catalogue Number: BPC 1003
Size: 0.1 mg

Purified from fresh citrated bovine plasma using a combination of salt precipitations and column chromatography. Protein purity is determined by SDS-PAGE and shows total reduction upon incubation with 2-mercaptoethanol. Protein C is activated to gthe serine protease, Activated Protein C (APC), by a-thrombin or the complex of a-thrombin/Thrombomodulin. This Activated Protein C is a potent anticoagulant through the selective inactivation of Factor Va and Factor VIIIa.

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Bovine Prothrombin (Factor II)

Catalogue Number: BP 1004
Size: 10 mg

Prepared from freshly collected bovine plasma. Bovine Prothrombin is a glycoprotein of molecular weight 70,000 and consists of a single polypeptide chain. Activation of Prothrombin by the Prothrombnase complex (FXa, FVa, PL and Ca++)yields the serine protease Thrombin. Prothrombin purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.

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Bovine Factor IX

Catalogue Number: BFIX 1005
Size: 0.5 mg

Prepared from freshly collected bovine plasma. Protein puriry is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Activated Factor IX (activated via Factor XIa or the Factor VIIa/tissue factor/phospholipid complex is responsible for the activation of Factor X to Xa.

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Bovine Factor X

Catalogue Number: BFX 1006
Size: 1.0 mg

Prepared from freshly collected bovine plasma. Bovine Factor X, when activated via the contact factor pathway or tissue factor pathway, is responsible for the conversion of Prothrombin to Thrombin. The protein purity is determined by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol.

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Bovine Plasminogen

Catalogue Number: BPg
Size: 1.0 mg

Purified from freshly collected bovine plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. No Plasmin activity is detected using chromogenic substrate S-2251. Plasminogen is activated to the serine protease plasmin via urokinase, streptokinase or tissue plasminogen activator.

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Enzymes

Bovine Activated Protein C

Catalogue Number: BPCa
Size: 0.1 mg

Activated Protein C is a serine protease derived from the two chain vitamin K dependent zymogen, Protein C. Activated Protein C inhibits blood coagulation through the selective inactivation of the cofactors Va and VIIIa. Activated Protein C is prepared from homogeneous protein C by activation with purified a-thrombin. This a-thrombin is removed after activation by ion exchange chromatography. Activated Protein C is homogeneous on 10% SDS-PAGE gels and shows complete reduction upon incubation with 2-mercaptoethanol.

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Bovine Alpha Thrombin (Factor IIa)

Catalogue Number: BT 1002a
Size: 1000 units

Prepared from Bovine Prothrombin through activation via the prothrombinase complex (FXa, FVa, PL and Ca++). Bovine a-Thrombin purity is determined by SDS-PAGE. This activated enzyme has a minmum activity of 1,800 NIH units/mg when compared to NIH standard human thrombin.

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Bovine Factor IXa,b

Catalogue Number: BFIXa 1080
Size: 0.5 mg

Prepared from Bovine Factor IX by activation with Bovine Factor XIa. This Bovine Factor XIa is removed after activation. Complete activation is observed by SDS-PAGE. The Factor XIa activates Factor IX in a two step reaction. In the first step, an internal Arg-Ala bond is cleaved, and in the second step a Arg-Val bond is cleaved. The second cleavage leads to the liberation of an activation peptide from the NH2-terminal portion of the heavy chain to produce Factor IXa,b.

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Bovine Factor Xa

Catalogue Number: BFXa
Size: 1.0 mg

Bovine Factor Xa is prepared from Bovine Factor X by activation with Russell's Viper Venom (RVV-X). This RVV-X is removed after activation. Complete activation is observed by SDS-PAGE. Factor Xa, as part of the prothrombinase complex along with Factor Va, phospholipids and calcium ions, catalyses the rapid conversion of Prothrombin to Thrombin.

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Bovine Factor XIa

Catalogue Number: BFXIa 11a
Size: 1.0 mg

Bovine Factor XIa is purified from freshly collected bovine plasma using a combination of salt precipitations and activation on a negative surface. This Factor XIa is a potent activator of both Human and Bovine Factor IX. Bovine Factor XIa purity is determined by SDS-PAGE and shows complete reduction upon 2-mercaptoethanol.

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Cofactors

Bovine Factor V/ Va

Catalogue Number: BFV/Va
Size: 1.0 mg

Purified from freshly collected bovine plasma using a combination of salt precipitations and column chromatography. This protein is a mixture of Factor V/Va and intermediate activation products as judged by 4-20% gradient gels. Bovine Factor Va functions as a cofactor with the serine protease Factor Xa in the activation of prothrombin. This protein may be used as a source of V/Va in the Prothrombinase complex.

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Inhibitors

Bovine Antithrombin

Catalogue Number: BAT
Size: 1.0 mg

Purified from freshly collected bovine plasma. BAT is a single chain glycoprotein which is considered to be the main physiological inhibitor of Thrombin and Factor Xa. Bovine Antithrombin purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.

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Fibrinogen

Bovine Fibrinogen, Plasminogen Depleted

Catalogue Number: BFIB 1
Size: 1.0 gm

Purified form fresh collected bovine plasma. The protein purity is determined by SDS-PAGE and is greater than 95 % clottable. Conversion of soluble Fibrinogen to the insoluble clot forming fibrin is the terminal stage of blood coagulation.

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