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Human Coagulation

Fibrinogen

Human Fibrinogen, Plasminogen Depleted

Catalogue Number: FIB 1
Size: 1.0 gm

Purified from fresh frozen plasma. Human Fibrinogen, Plasminogen Depleted is homogeneous on 4-20 % SDS-PAGE gels and is greater than 95 % clottable. No other coagulation factors are detected by functional assay. Conversion of soluble Fibrinogen to the insoluble clot-forming fibrin is the terminal stage of blood coagulation.

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Human Fibrinogen, von Willebrand Factor and Plasminogen Depleted

Catalogue Number: FIB 2
Size: 1.0 gm

Purified from fresh frozen plasma, this protein has been purified using a combination of salt precipitations, affinity and immunoaffinity resins to remove Plasminogen and von Willebrand Factor. In a functional assay this protein is greater than 95 % clottable and is homogeneous on 4-20 % SDS-PAGE gels.

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Human Fibrinogen, Plasminogen, von Willebrand Factor and Fibronectin Depleted

Catalogue Number: FIB 3
Size: 1.0 gm

Purified from fresh frozen plasma, this protein has been purified using a combination of salt precipitations, affinity and immunoaffinity resins to remove Plasminogen, von Willebrand Factor and Fibronectin. In a functional assay this protein is greater than 95 % clottable and is homogeneous on 4-20 % SDS-PAGE gels.

(Product is packaged as 4 x 0.25 gm vials)

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Human Peak '1' Purified Fibrinogen (Factor XIII free)

Catalogue Number: P1FIB (XIII free)
Size: 10.0 mg

Human Peak '1' Fibrinogen accounts for 85% of the total plasma Fibrinogen. It contains mostly intact Aα subunit chains, is free of plasminogen, factor XIII, fibronectin, and other non-fibrinogen protein contaminants. Peak '1' Fibrinogen molecules each contain two copies of the platelet-binding γA chain C-terminal sequence and are ideal substrates for factor XIII assay.

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Human Peak '2' Purified Fibrinogen

Catalogue Number: P2FIB
Size: 10.0 mg

Human Peak '2' Fibrinogen accounts for 15% of the total plasma fibrinogen. It contains measurable amonts of factor XIII activity because the factor XIII B subunits bind to the γ chains and bring catalytic A subunits along with them. Thus Peak '2' fibrinogen serves as a 'carrier' for factor XIII in blood. The γ chain lacks the platelet recognition sequence but like all γ chains becomes crosslinked to dimers by factor XIIa.

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