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Human Coagulation

Inhibitors

Human a2-Antiplasmin

Catalogue Number: a2-AP
Size: 0.1 mg

Human a2-Antiplasmin, also known as Human α2-Plasmin Inhibitor, is a plasma glycoprotein that is a member of the SERPIN family of proteinase inhibitors. Human a2-Antiplasmin is the primary fast-acting inhibitor of plasmin in vivo, but has also been reported to inhibit other enzymes such as trypsin, elastase and Human Activated Protein C. Human a2-Antiplasmin is purified from normal human plasma using immunoaffinity and ion-exchange chromatography. Purified Human a2-Antiplasmin activity is determined by titration with purified plasmin.

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Human Thrombin Activatable Fibrinolysis Inhibitor (TAFI)

Catalogue Number: TAFI
Size: 0.1 mg

Thrombin Activatable Fibrinolysis Inhibitor (TAFI), also known as plasma procarboxypeptidase-B and carboxypeptidase-U, is a single chain glycoprotein with a mass of 58,000 daltons. TAFI is purified from normal human plasma using immunoaffinity and ion-exchange chromatography.

 

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Human Antithrombin

Catalogue Number: HAT
Size: 1.0 mg

Purified from fresh frozen human plasma. AT is a single chain glycoprotein which is considered to be the main physiological inhibitor of Thrombin and Factor Xa. In the presence of heparin, the inhibition of Thrombin and Factor Xa is enhanced from 300 to 1,000 fold. AT purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.

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Human Heparin Cofactor II (HCII)

Catalogue Number: HCII
Size: 0.5 mg

Prepared from fresh frozen human plasma. Heparin Cofactor II is a single chain glycoprotein with a MW of 65,600 daltons. HCII is a specific inhibitor of Thrombin with increased activity in the presence of heparin. HCII purity is determined by SDS-PAGE and the activity is measured by the ability to inhibit Thrombin in the presence of saturating concentrations of heparin.

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Hirudin (HV-1)

Catalogue Number: Hir
Size: 0.1 mg

Prepared as a recombinant protein with Tyr-63 not sulphated. The 65 amino acid polypeptide is homogeneous as judged by 20% SDS-PAGE. Hirudin reacts rapidly with Thrombin to form a tight complex with a dissociation constant in the femtomolar range.

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Corn Trypsin Inhibitor

Catalogue Number: CTI
Size: 1.0 mg

Corn Trypsin Inhibitor (CTI) is a specific and potent inhibitor of Human Factor XIIa. It is purified from fresh Indiana sweet corn by solvent extraction and chromatographic methods. A suggested inhibitory concentration is 25 fold molar excess over the enzyme concentration. CTI purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.

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