Mon-Fri 9am to 5pm GMT
+44 (0)1792 686070

Human Coagulation

Zymogens

Human Prothrombin (Factor II)

Catalogue Number: HP 1002
Size: 9.0 mg

Prepared from fresh frozen human plasma. Human Prothrombin is a glycoprotein of molecular weight 72,000 and consists of a single polypeptide chain. Activation of Human Prothrombin by Human Factor Va, Human Factor Xa and phospholipids yields the serine protease Human Alpha Thrombin. Human Prothrombin purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol.

More Info

Human Prothrombin Fragment 1

Catalogue Number: F1
Size: 1.0 mg

Prepared from fresh frozen human plasma. Human Prothrombin Fragment 1 is a glycoprotein of molecular weight 21,700 and consists of a single polypeptide chain.

More Info

Human Prothrombin Fragment 2

Catalogue Number: F2
Size: 1.0 mg

Prepared from fesh frozen human plasma. Human Prothrombin Fragment 2 is a glycoprotein of molecular weight 12,866 and consists of a single polypeptide chain.

More Info

Human Factor VII

Catalogue Number: HFVII 1007
Size: 0.1 mg

Prepared from fresh frozen human plasma. Human Factor VII is a single chain vitamin K-dependent glycoprotein found in trace quantities in plasma (0.5 mg/Liter). In the Tissue Factor Pathway of coagulation, Human Factor VIIa, in the presence of calcium ions and tissue factor, activates Human Factor IX and Human X to their enzymatically active forms, Human Factor IXa and Human Factor Xa. Purity of Human Factor VII is determined by SDS-PAGE.

More Info

Human Protein C

Catalogue Number: HPC 1001
Size: 0.1 mg

Human Protein C is purified from fresh frozen human plasma using a combination of salt precipitations and column chromatography. The Human Protein C purity is determined by SDS-PAGE and shows total reduction upon incubation with 2-mercaptoethanol. Human Protein C is activated to the serine protease, Human Activated Protein C (APC) by Human Thrombin or the complex of Human Thrombin / Human Thrombomodulin and is a potent anticoagulant through the selective inactivation of Human Factor Va and Human Factor VIIIa.

More Info

Human Factor IX

Catalogue Number: HFIX 1009
Size: 0.5 mg

Prepared from fresh frozen human plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Activity is determined via clotting assay. Human Factor IX, activated by either the Contact or Tissue Factor Pathway, is responsible for the activation of Factor X to Xa.

More Info

Human Factor X

Catalogue Number: HFX 1010
Size: 0.8 mg

Prepared from fresh frozen human plasma. The purity of this Vitamin K-dependent protein is determined by SDS-PAGE gels and shows total reduction upon incubation with 2-mercaptoethanol. Activity is determined via clotting assay. Human Factor X, once activated via the Contact Factor Pathway or Tissue Factor Pathway, is responsible for the conversion of Prothrombin to Thrombin.

More Info

Human Factor XI

Catalogue Number: HFXI 1111
Size: 0.1 mg

Prepared from fresh frozen human plasma. Human Factor XI is a glycoprotein of molecular weight 160,000. This protein migrates as a single band on 6 % SDS-PAGE gels in the absence of reducing agents. Human Factor XI is comprised of two identical polypeptide chains linked by disulphide bonds which yield a single band at 80,000 upon reduction with 2-mercaptoethanol. The specific clotting activity of purified Human Factor XI is 180-200 units/mg. In vivo, Factor XI is activated to Factor XIa by Factor XIIa. The resulting Human Factor XIa consists of two heavy and two light chains held together by disulphide bridges.

More Info

Human Factor XII

Catalogue Number: HXII 1212
Size: 0.5 mg

Purified from fresh frozen human plasma. Human Factor XII is part of the contact activation system. Human Factor XII is a single chain glycoprotein with a molecular weight of approximately 80,000. Once activated, principally from the action of Kallikrein, Factor XII is converted into the active serine protease (Factor a-XIIa) that functions in the in vivo initiation of blood coagulation, fibrinolysis and kinin formation. Human Factor XII has been purified by ion exchange chromatography. Protein purity is determined by SDS-PAGE and activity is determined via clotting assay.

More Info

Human Factor XIII

Catalogue Number: HFXIII 1313
Size: 0.25 mg

Human Factor XIII is a tetramer composed of two pairs of chains held together by non-covalent bonds. After activation of the zymogen via Thrombin to its active enzyme form, Factor XIIIa is responsible for catalyzing the formation of covalent bridges between fibrin units to increase the elasticity of the clot network. The resulting cross-linked fibrin is very insoluble and resistant to lysis. Enzyme Research Laboratories offers the zymogen form of Human Factor XIII (a2b2).

More Info

Human Prekallikrein

Catalogue Number: HPK 1302
Size: 1.0 mg

Purified from fresh frozen human plasma. Human Prekallikrein is a single chain gamma globulin glycoprotein that participates in the early phase of contract activation, kinin formation and fibrinolysis. Prekallikrein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. Activity is determined via clotting assay.

More Info

Single Chain High Molecular Weight Kininogen

Catalogue Number: HK 1300
Size: 1.0 mg

High Molecular Weight Kininogen (HK) is a non-enzymatic cofactor of the contact activation system. HK is thought to have two functions in the contact activation system. First, HK links Prekallikrein to a negatively charged surface thereby allowing activation of Kallikrein by surface bound Factor a-XIIa. HK also forms a complex with Factor XI and accelerates its activation to XIa by a-XIIa. Additionally HK serves as a source of Bradykinin, a potent vasoactive peptide important in hypotension studies. The protein purity is determined by SDS-PAGE.

More Info

Two Chain High Molecular Weight Kininogen

Catalogue Number: 2HK 1301
Size: 1.0 mg

ERL offers the two chain Kinin-free form of Kininogen. This is prepared by Kallikrein digestion of Kininogen which is then repurified to remove traces of Kallikrein.

More Info

Human Glu-Plasminogen

Catalogue Number: HPG 2001
Size: 1.0 mg

Purified from fresh frozen human plasma. The protein purity is determined by SDS-PAGE and shows no reduction upon incubation with 2-mercaptoethanol. No plasmin activity is detected using the chromogenic substrate S-2251. Plasminogen is activated to the serine protease Plasmin via urokinase, streptokinase or tissue plasminogen activator.

More Info

Human Lys-Plasminogen

Catalogue Number: LPG 2002
Size: 1.0 mg

Purified from homogeneous Glu-Plasminogen by activation with Plasmin. This activation results in the release of a 76 amino acid peptide (Glu-Lys76). This Lys 77- Plasminogen can be readily converted to Lys 77-Plasmin by any of the common plasminogen activators. The protein purity is determined by SDS-PAGE.

More Info

Quick Contact