- Human Coagulation
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- r2 Diagnostics
Human Factor Alpha XIIa
Size: 0.5 mg
Human Factor a-XIIa is a serine protease responsible for the activation of Factor XI to XIa in the contact activation system. Human Factor XII and Prekallikrein are thought to be involved in a reciprocal activation mechanism in which XIIa activates Prekallikrein to Kallikrein which in turn converts Factor XII to XIIa. Factor XIIa activates Factor XI to XIa thereby triggering the Contact Factor cascade. Enzyme Research Laboratories offers Factor a-XIIa which is activated by the autoactivation process with Dextran Sulphate and re-purified to remove the activator. The protein purity is determined by SDS-PAGE and activity is determined via clotting assay.
Buffer Composition = 4 mM Sodium Acetate-HCl / 0.15 M NaCl / pH 5.3
Extinction Coefficient (1%) = 14.1
Molecular Weight = 80,000 daltons
Supplied LYOPHILIZED. Shipped at ambient temperature.
Human Factor XII
Human Factor XIIa beta