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Human Coagulation

Platelet & Plasma Proteins

Human Platelet Factor 4 (PF4)

Catalogue Number: PF4
Size: 0.1 mg

Platelet Factor 4 is purified from Human platelets by affinity chromatography and gel filtration. Platelet Factor 4 has a molecular weight of 29,000 daltons and is made up of 4 identical subunits of 7,800 daltons each.

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Human Apolipoprotein-H (B2-Glycoprotein-1)

Catalogue Number: HAPO-H
Size: 0.1 mg

B2Glycoprotein-1 (B2GP-1), also known as Apolipoprotein-H is a plasma glycoprotein that circulates at a concentration of 200 ug/ml (4 uM). B2GP-1 has been identified as a constituent of chylomicrons, very low density lipoproteins and high density lipoproteins in human plasma. It has also been demonstrated to bind phospholipids, heparin and platelets where it can modulate the activity of adenylate (19%). Although the precise function(s) are as yet unknown, B2GP-1 has been shown to interfere with blood coagulation by competitively binding to phospholipids exposed during cell activation or damage. Recent evidence also implicates B2GP-1 as a cofactor recognized by some anti-phospholipid antibodies present in autoimmune disorders such as systemic lupus erythematosus (SLE).

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Catalogue Number: GP2b3a
Size: 1.0 mg

Platelet membrane glycoproteins are involved in platelet adhesion and aggregation. Glycoproteins IIb and IIIa (GPIIb and GPIIIa) constitute the fibrinogen receptor and are required for platelet aggregation. Enzyme Research Laboratories offers GPIIbIIIa purified from human platelets. Glycoprotein IIb consists of 2 disulfide-linked subunits GPIIb, (MW = 125,000) and GPII (MW 23,000) while GPIIIa has only one polypeptide chain (MW 108,000), reduced). Human GPIIbIIIa migrates on gels as follows: GPIIb 136,000 non-reduced and 125,000 reduced. GPIIIa is 97,000 non-reduced and 108,000 reduced. Protein concentration is determined by the Bradford method.

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