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Human Factor XIa

Catalogue Number: HFXIa 1111a
Size: 0.1 mg

Prepared from Human Factor XI using Human Factor XIIa. This XIIa is removed using a corn trypsin inhibitor column. Complete activation is observed by SDS-PAGE. Factor XI, through the contact factor pathway cascade, is activated to Factor XIa via Factor XIIa and High Molecular Weight Kininogen. During activation by Factor XIIa and HK, FXI undergoes proteolytic cleavage in which the Mr=80,000 chain reportedtly is cleaved to a heavy and light chain with Mr of about 48,000 and 33,000. This Factor XIa is responsible for the activation of Factor IX to Factor IXa. Unlike other examples of activation of vitamin K-dependant blood-clotting proteins, Factor XIa proteolysis of Factor IX does not require membrane surfaces.

Buffer composition = 2 mM Sodium Acetate-HCl / 0.075 M NaCl / 50% (v/v) Glycerol / pH 5.3

Extinction Coefficient (1%) = 13.1

Molecular Weight = 160,000 daltons.

 

Supplied in LIQUID form. Shipped on ice packs.

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