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Human Kallikrein

Catalogue Number: HPKa 1303
Size: 1.0 mg

Activation of Prekallikrein with Factor a-XIIa produces the enzymatically active Kallikrein. Kallikrein is a serine protease which consists of a heavy chain (molecular weight 52,000) and light chains (molecular weights either 36,000 or 33,000) linked by disulphide bridges. Kallikrein possesses enzymatic activity towards Factor XII, High Molecular Weight Kininogen, Plasminogen, Factor XI, Factor IX, Factor VII, prorenin and the complement system. After activation, the activating enzyme Factor XIIa is removed by affinity chromatography. Human Kallikrein purity is determined by SDS-PAGE and shows complete reduction upon incubation with 2-mercaptoethanol.

Buffer Composition = 4 mM Sodium Acetate-HCl / 0.15 M NaCl / pH 5.3

Extinction Coefficient (1%) = 11.7

Molecular Weight = ~86,000 daltons

 

Supplied LYOPHILIZED. Shipped at ambient temperature.

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Human Prekallikrein
Human Factor Alpha XIIa

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