Protac

Catalogue Number: 113-01
Size: 5 x 3 U vials

Protac, a single chain glycoprotein, is a fast acting Protein C activator isolated from the venom of the copperhead snake Agkistrodon contortrix. It rapidly converts Protein C into Activated Protein C which may be determined either by measuring its prolonging effect on the activated partial thromboplastin time (APTT) or by measuring its enzyme activity by means of a specific chromogenic substrate.

Protac is used for the determination of Protein C and Protein S levels in plasma.

Packsize contains - 5 x 3 U vials

Vial Size = 5 x 3 U vials packsize

Molecular Weight 36000 - 42000 daltons

Supplied LYOPHILIZED. Shipped at ambient temperature.

References

1. Kraus M, Noah M, Fickenscher K: The PCAT - A simple screening assay for assessing the functionality of the protein C anticoagulant pathway. Throm Res 1995 79: 217-22

2. Meier J, Stocker K: Snake venom protein C activators. In: Handbook of Natural Toxins, Reptile Venoms and Toxins. Tu AT, ed. New York: Marcel Dekker 1990: 265-79

3. Robert A, Eschwege V, Hameg H, Drouet L, Aillaud MF: Anticoagulant response to Agkistrodon contortix venom (ACV test): a new global test to screen for defects in the anticoagulant protein C pathway. Thromb Haemost 1996 75: 562-6

4. Stocker K, Fischer H, Meier J, Brogli M, Svendsen L: Charatcertisation of the protein C activator Protac from the venom of the southern copperhead (Agkistrodon contortix) snake. Toxicon 1987 25: 239-52

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Protac

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