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Human Alpha Thrombin (Factor IIa)

Catalogue Number: HT 1002a
Size: 1000 NIH U

Prepared from Human Prothrombin by activation with Human Factor Xa, Human Factor Va and phospholipid. Human Alpha Thrombin purity is determined by SDS-PAGE. Human Alpha Thrombin has a minimum activity of 2,700 NIH units/mg when compared to NIH standard Human Alpha Thrombin (WHO 2nd International Standard for Thrombin 01/580).

 

Human Alpha Thrombin

Buffer Composition = 50 mM Sodium Citrate / 0.2 M NaCl / 0.1% PEG-8000 / pH 6.5

Extinction Coefficient (1%) = 18.3

Molecular Weight = 37,000 daltons

Supplied LYOPHILIZED. Shipped at ambient temperature.

 

References

1. Crawley JTB, Zanardelli, CK, Chion, NK, Lane, DA: The central role of thrombin in hemostasis. J Thromb Haemost 2007 (5) (Suppl 1): 95-101

2. Lundblad RL, Bradshaw RA, Gabriel D, Ortel TL, Lawson J, Mann KG: A review of the therapeutic uses of thrombin. Thromb Haemost 2004 91(5): 851-60

3. CPR Walker, D Royston: Thrombin generation and its inhibition: a review of the scientific basis and mechanism of action of anticoagulant therapies. Br J Anaesth 2002 88(6): 848-863

4. Church FC, Pratt CW, Noyes CM, Kalayanamit T, Sherrill GB, Tobin RB, Meade JB: Structural and functional properties of human alpha-thrombin, phosphopyridoxylated alpha-thrombin, and gamma T-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactions. J Biol Chem 1989 264(31):18419-18425

5. Wilson R, Cossins A, Nicolau DV Missailidis S: The selection of DNA aptamers for two different epitopes of thrombin was not due to different partitioning methods. Nucleic Acid Ther 2013 23(1): 88–92  

 

 

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